Urinary metabolites of organic solvents

Urinary Organic Metabolites

Studies of gas chromatography/mass spectrometry (GC-MS) techniques carried out in 1994 on human clinical samples had already suggested a “potential for diagnosis and studies of metabolism in situ” . Researchers found that, when this technique is applied to blood or urine, it gives an insight into the infected host microbial metabolism . A more recent study (2002) on urinary organic metabolites,...

Quantitative determination of urinary metabolites in subjects exposed to organic solvents.

Most of the common organic solvents are excreted into urine as metabolites. A correlation exists for several organic solvents between the amount taken in and the amount of metabolites excreted. Many methods have been developed for the measurement of these urinary metabolites. The methods were classified into three group: colorimetry, gas chromatography and high performance liquid chromatography...

Evaluation of exposure to mixed solvents by analysis of urinary metabolites and solvents: content ranges.

To evaluate worker's exposure to mixed solvents, equations for the calculation of the biological hazard index, which is defined as biological levels tolerable for exposure to mixture, were developed. When biological levels of exposure indicators were not affected by coexposure, rules similar to those for airborne monitoring could be applied. Namely, when the components had additive effects, the...

Toxicity of metabolites to dopaminergic systems and the behavioural effects of organic solvents.

NMR Chemical Shift Ranges of Urine Metabolites in Various Organic Solvents

Signal stability is essential for reliable multivariate data analysis. Urine samples show strong variance in signal positions due to inter patient differences. Here we study the exchange of the solvent of a defined urine matrix and how it affects signal and integral stability of the urinary metabolites by NMR spectroscopy. The exchange solvents were methanol, acetonitrile, dimethyl sulfoxide, c...